German Value Set for the EQ-5D-5L

authored by: Kristina Ludwig, J. Matthias Graf von der Schulenburg, Wolfgang Greiner
Abstract: Objectives: The objective of this study was to develop a value set for EQ-5D-5L based on the societal preferences of the German population. As the first country to do so, the study design used the improved EQ-5D-5L valuation protocol 2.0 developed by the EuroQol Group, including a feedback module as internal validation and a quality control process that was missing in the first wave of EQ-5D-5L valuation studies. Methods: A representative sample of the general German population (n = 1158) was interviewed using a composite time trade-off and a discrete choice experiment under close quality control. Econometric modeling was used to estimate values for all 3125 possible health states described by EQ-5D-5L. The value set was based on a hybrid model including all available information from the composite time trade-off and discrete choice experiment valuations without any exclusions due to data issues. Results: The final German value set was constructed from a combination of a conditional logit model for the discrete choice experiment data and a censored at −1 Tobit model for the composite time trade-off data, correcting for heteroskedasticity. The value set had logically consistent parameter estimates (p < 0.001 for all coefficients). The predicted EQ-5D-5L index values ranged from −0.661 to 1. Conclusions: This study provided values for the health states of the German version of EQ-5D-5L representing the preferences of the German population. The study successfully employed for the first time worldwide the improved protocol 2.0. The value set enables the use of the EQ-5D-5L instrument in economic evaluations and in clinical studies.
Organisation(s): Institute of Insurance Business Administration
External Organisation(s): Bielefeld University
Type: Article
Journal: PHARMACOECONOMICS
Volume: 36
Pages: 663-674
No. of pages: 12
ISSN: 1170-7690
Publication date: 06.2018
Publication status: Published
Peer reviewed: Yes
ASJC Scopus subject areas: Pharmacology, Health Policy, Public Health, Environmental and Occupational Health
Sustainable Development Goals: SDG 3 - Good Health and Well-being
Electronic version(s): https://doi.org/10.1007/s40273-018-0615-8 (Access: Open)