Graphitic Carbon Coated Magnetite Nanoparticles for Dual Mode Imaging and Hyperthermia

authored by

Ashish Tiwari, Navneet C. Verma, Sibel Turkkan, Ayan Debnath, Anup Singh, Gerald Dräger, Chayan K. Nandi, Jaspreet K. Randhawa

Abstract

Correlating the optical properties to the magnetic properties in superparamagnetic iron oxide (Fe₃O₄) nanoparticles (SPIONs) will be a boost for future biomedical applications. However, designing such SPIONs without altering its properties is a real challenge. Here, we demonstrate the engineering of the magneto-fluorescent properties simply by tuning the carbon structure in graphitic carbon coated SPIONs. By synthesizing three distinct nanostructures in an easy single step process and studying the in depth structural-functional relationship, we found that the thickness of carbon shell decides the fate of magneto-fluorescent characteristics in SPIONs. Single particle fluorescence data show that the number of emissive photon increases substantially with the increase in the thickness of carbon shell, albeit, the observed relaxivity was enough to get high quality magnetic resonance imaging. The ex vivo magnetic hyperthermia results advanced the use of SPIONs as a single platform for cancer theranostics.

Organisation(s)

Institute of Organic Chemistry

External Organisation(s)

Indian Institute of Technology Delhi (IITD)
Indian Institute of Technology Mandi (IITMandi)

Type

Article

Journal

ACS Applied Nano Materials

Volume

3

Pages

896-904

No. of pages

9

Publication date

24.01.2020

Publication status

Published

Peer reviewed

Yes

ASJC Scopus subject areas

Materials Science(all)

Sustainable Development Goals

SDG 3 - Good Health and Well-being

Electronic version(s)

https://doi.org/10.1021/acsanm.9b02501 (Access: Closed)