Total Synthesis of Aetheramide A
- authored by
- Lisa Gerstmann, Markus Kalesse
- Abstract
The first total synthesis of the highly potent anti-HIV natural product aetheramide A was accomplished in 18 steps from four equally complex building blocks. The synthesis established the unknown configuration at C26 and used a configurationally labile β-ketoester moiety for the self-adjustment of the configuration at a methyl branch. The pivotal macrolactamization was achieved by trapping a thermally generated acylketene which was derived from its corresponding dioxinone.
- Organisation(s)
-
Institute of Organic Chemistry
- External Organisation(s)
-
Helmholtz Centre for Infection Research (HZI)
- Type
- Article
- Journal
- Chemistry - a European journal
- Volume
- 22
- Pages
- 11210-11212
- No. of pages
- 3
- ISSN
- 0947-6539
- Publication date
- 27.07.2016
- Publication status
- Published
- Peer reviewed
- Yes
- ASJC Scopus subject areas
- Catalysis, Organic Chemistry
- Sustainable Development Goals
- SDG 3 - Good Health and Well-being
- Electronic version(s)
-
https://doi.org/10.1002/chem.201602682 (Access:
Closed)
