Application of adaptive interim analysis in pharmacology

authored by

Ludwig A. Hothorn, Ullrich Martin

Abstract

A Drug Information Association Workshop on “Statistical Methodology on Non-Clinical and Toxicological Studies” was held March 25–27, 1996. The purpose of this meeting was to discuss the appropriateness of current and new biostatistical methods in this field of drug development. This paper describes the application of adaptive interim analysis in pharmacological studies. Bauer and Köhne (1) published a two-step approach in the case of unknown a priori information. This approach is now widely used for clinical trails. Here, the advantages of use in some pharmacological studies will be discussed.

Organisation(s)

Department of Biostatistics

External Organisation(s)

F. Hoffmann-La Roche AG

Type

Article

Journal

Therapeutic Innovation & Regulatory Science

Volume

31

Pages

615-619

No. of pages

5

ISSN

2168-4790

Publication date

30.12.1997

Publication status

Published

Peer reviewed

Yes

ASJC Scopus subject areas

Pharmacology, Toxicology and Pharmaceutics (miscellaneous), Public Health, Environmental and Occupational Health, Pharmacology (medical)

Sustainable Development Goals

SDG 3 - Good Health and Well-being

Electronic version(s)

https://doi.org/10.1177/009286159703100229 (Access: Closed)
https://doi.org/10.15488/2981 (Access: Open)