c-di-GMP signalling and the regulation of developmental transitions in streptomycetes

authored by

Matthew J Bush, Natalia Tschowri, Susan Schlimpert, Klas Flärdh, Mark J Buttner

Abstract

The complex life cycle of streptomycetes involves two distinct filamentous cell forms: the growing (or vegetative) hyphae and the reproductive (or aerial) hyphae, which differentiate into long chains of spores. Until recently, little was known about the signalling pathways that regulate the developmental transitions leading to sporulation. In this Review, we discuss important new insights into these pathways that have led to the emergence of a coherent regulatory network, focusing on the erection of aerial hyphae and the synchronous cell division event that produces dozens of unigenomic spores. In particular, we highlight the role of cyclic di-GMP (c-di-GMP) in controlling the initiation of development, and the role of the master regulator BldD in mediating c-di-GMP signalling.

External Organisation(s)

John Innes Centre
Humboldt-Universität zu Berlin (HU Berlin)
Lund University

Type

Article

Journal

Nature Reviews Microbiology

Volume

13

Pages

749-760

No. of pages

12

ISSN

1740-1526

Publication date

01.12.2015

Publication status

Published

ASJC Scopus subject areas

Infectious Diseases, General Immunology and Microbiology, Microbiology

Sustainable Development Goals

SDG 3 - Good Health and Well-being

Electronic version(s)

https://doi.org/10.1038/nrmicro3546 (Access: Closed)