Synthesis of a cytotoxic ansamycin hybrid
- authored by
- Gerrit Jürjens, Andreas Kirschning
- Abstract
The synthesis of a new ansamycin macrolactam derivative that contains an ansa chain based on ansamitocin and an aromatic core related to geldanamycin is reported. The selective introduction of the cyclic carbamoyl group at C7 and C9 relies on a biotransformation using a mutant strain of S. hygroscopicus, the geldanamycin producer. The ansamycin hybrid forms atropisomers that differ in their antiproliferative activity toward cancer cells.
- Organisation(s)
-
Institute of Organic Chemistry
Centre of Biomolecular Drug Research (BMWZ)
- Type
- Article
- Journal
- Organic Letters
- Volume
- 16
- Pages
- 3000-3003
- No. of pages
- 4
- ISSN
- 1523-7060
- Publication date
- 29.05.2014
- Publication status
- Published
- Peer reviewed
- Yes
- ASJC Scopus subject areas
- Biochemistry, Physical and Theoretical Chemistry, Organic Chemistry
- Sustainable Development Goals
- SDG 3 - Good Health and Well-being
- Electronic version(s)
-
https://doi.org/10.1021/ol5011278 (Access:
Closed)
