Cyclization of synthetic seco-proansamitocins to ansamitocin macrolactams by actinosynnema pretiosum as biocatalyst
- authored by
- Kirsten Harmrolfs, Marco Brünjes, Gerald Dräger, Heinz G. Floss, Florenz Sasse, Florian Taft, Andreas Kirschning
- Abstract
Ring closure is possible with seco-proansamitocin and two activated SNAC esters, which can be processed to ansamitocin P3 and 19-deschloro-20-demethoxy AP-3, respectively, by an AHBA-blocked mutant of Actinosynnema pretiosum. This work sheds light on the synthetic potential of macrolactamizing amide synthases. The new ansamitocin derivative showed similar to enhanced antiproliferative activity against several cancer cell lines relative to AP-3.
- Organisation(s)
-
Institute of Organic Chemistry
Centre of Biomolecular Drug Research (BMWZ)
- External Organisation(s)
-
University of Washington
Helmholtz Centre for Infection Research (HZI)
- Type
- Article
- Journal
- ChemBioChem
- Volume
- 11
- Pages
- 2517-2520
- No. of pages
- 4
- ISSN
- 1439-4227
- Publication date
- 10.12.2010
- Publication status
- Published
- Peer reviewed
- Yes
- ASJC Scopus subject areas
- Biochemistry, Molecular Medicine, Molecular Biology, Organic Chemistry
- Sustainable Development Goals
- SDG 3 - Good Health and Well-being
- Electronic version(s)
-
https://doi.org/10.1002/cbic.201000422 (Access:
Unknown)
