Development of a combined OCT-Raman probe for the prospective in vivo clinical melanoma skin cancer screening

authored by

Mikhail Mazurenka, Lea Behrendt, Merve Wollweber, Uwe Morgner, Bernhard Wilhelm Roth

Abstract

A combined optical coherence tomography (OCT)-Raman probe was designed and built into a spectral domain OCT head, and its performance was evaluated and compared to the most common Raman probe setups, based on a fiber bundle and confocal free space optics. Due to the use of the full field of view of an OCT scanning lens, the combined probe has a superior performance within maximum permissible exposure limits, compared to the other two probes. Skin Raman spectra, recorded in vivo, further prove the feasibility of the OCT-Raman probe for the future in vivo clinical applications in skin cancer screening.

Organisation(s)

Hannover Centre for Optical Technologies (HOT)
Institute of Quantum Optics

Type

Article

Journal

Review of Scientific Instruments

Volume

88

ISSN

0034-6748

Publication date

04.10.2017

Publication status

Published

Peer reviewed

Yes

ASJC Scopus subject areas

Instrumentation

Sustainable Development Goals

SDG 3 - Good Health and Well-being

Electronic version(s)

https://doi.org/10.1063/1.5004999 (Access: Closed)