Use of antidementia drugs in German patients with Alzheimer's disease

authored by

Philipp Hessmann, Richard Dodel, Erika Baum, Matthias J. Müller, Greta Paschke, Bernhard Kis, Jan Zeidler, Mike Klora, Jens Peter Reese, Monika Balzer-Geldsetzer

Abstract

The objective of this study was to evaluate the use of antidementia drugs (ADDs) in patients with Alzheimer's disease (AD) regarding German guideline recommendations and to assess correlations between the use of ADDs and the patients' characteristics. A total of 395 community-dwelling and institutionalized patients with AD across all severity stages of dementia were recruited in this cross-sectional study. Associations between the prescription of ADDs and patients' sociodemographic and clinical parameters (neuropsychiatric symptoms, cognitive capacity, daily activities, and health-related quality of life) were analyzed in multiple logistic regression analyses. ADDs were prescribed in 46.6% of all participants and less often in institutionalized patients (38.2 vs. 50.4%, P=0.025). Patients with mild-to-moderate dementia had a higher chance of receiving ADDs [odds ratio (OR)=3.752, 95% confidence interval (CI): 1.166-12.080 and OR=3.526, 95% CI: 1.431-8.688] as well as those treated by neurologists/psychiatrists (OR=2.467, 95% CI: 1.288-4.726). Overall, 39% of the patients with mild cognitive deficits (Mini-Mental Status Examination 27-30) received ADDs and 21% of the mildly demented patients (Mini-Mental Status Examination 20-26) received memantine. The treatment with ADDs was in part not in line with German guideline recommendations. Particularly, the lower use of ADDs in patients not attending neuropsychiatric specialists should be further evaluated.

Organisation(s)

Center for Health Economics Research Hannover (CHERH)

External Organisation(s)

University of Göttingen
Philipps-Universität Marburg
University of Duisburg-Essen
Justus Liebig University Giessen
Praxis Alexander Etz
Oberberg Fachkliniken

Type

Article

Journal

International Clinical Psychopharmacology

Volume

33

Pages

103-110

No. of pages

8

ISSN

0268-1315

Publication date

03.2018

Publication status

Published

Peer reviewed

Yes

ASJC Scopus subject areas

Psychiatry and Mental health, Pharmacology (medical)

Sustainable Development Goals

SDG 3 - Good Health and Well-being

Electronic version(s)

https://doi.org/10.1097/YIC.0000000000000205 (Access: Closed)