Total synthesis of thuggacin B
- authored by
- Martin Bock, Richard Dehn, Andreas Kirschning
- Abstract
Final proof of the complete structures of thuggacins A-C was gained by a highly convergent and flexible total synthesis. Notable features include a substrate-controlled, titanium-mediated aldol reaction, a cross-metathesis approach for converting terminal alkenes into the corresponding vinyl iodides, and the cross-coupling of a complex vinyl iodide and terminal alkyne in the Sonogashira reaction. (Chemical Equation Presented).
- Organisation(s)
-
Institute of Organic Chemistry
Centre of Biomolecular Drug Research (BMWZ)
- Type
- Article
- Journal
- Angewandte Chemie
- Volume
- 47
- Pages
- 9134-9137
- No. of pages
- 4
- ISSN
- 1433-7851
- Publication date
- 05.11.2008
- Publication status
- Published
- Peer reviewed
- Yes
- ASJC Scopus subject areas
- Catalysis, General Chemistry
- Sustainable Development Goals
- SDG 3 - Good Health and Well-being
- Electronic version(s)
-
https://doi.org/10.1002/anie.200803271 (Access:
Closed)
https://doi.org/10.1002/anie.200803271 (Access: Closed)
