Folate and Prevention of neural tube defects: new insights from a bayesian model

authored by

A. Ströhle, T.  Bohn

Abstract

Maternal folate status before and during pregnancy influences a woman's risk of having a pregnancy affected by congenital malformations of the neural tube (neural tube defects, NTD). For NTD prevention, it is recommended that women use periconceptional supplementation of folic acid. However, the recommended dose varies considerably (400 - 800 μg folic acid/day). Insufficient data exists on the relation between folate status and the risk of NTD. A recent study published in the British Medical Journal provides evidence for a generalizable dose-response relation between folate status and risk of NTD. The lowest risk of having a child with NTD was related to red blood cell (RBC) folate concentrations of ≥ 1000 nmol/L.

Organisation(s)

Institute of Food Science and Human Nutrition
Nutrition Physiology and Human Nutrition Section

External Organisation(s)

Institute of Science and Technology, Luxembourg

Type

Article

Journal

International Journal for Vitamin and Nutrition Research

Volume

85

Pages

109-111

No. of pages

3

ISSN

1664-2821

Publication date

2015

Publication status

Published

Peer reviewed

Yes

ASJC Scopus subject areas

Medicine (miscellaneous), Endocrinology, Diabetes and Metabolism, Nutrition and Dietetics

Sustainable Development Goals

SDG 3 - Good Health and Well-being

Electronic version(s)

https://doi.org/10.1024/0300-9831/a000229 (Access: Closed)