Unaltered left ventricular mechanics and remodelling after 12 weeks of resistance exercise training

a longitudinal study in men

authored by: Jason S. Au, Sara Y. Oikawa, Robert W. Morton, Stuart M. Phillips, Maureen J. Macdonald, Eric J. Stöhr
Abstract: Previous longitudinal studies suggest that left ventricular (LV) structure is unaltered with resistance exercise training (RT) in young men. However, evidence from aerobic exercise training suggests that early changes in functional LV wall mechanics may occur prior to and independently of changes in LV size, although short-term changes in LV mechanics and structural remodelling in response to RT protocols have not been reported. Therefore, the purpose of this study was to examine the effects of RT on LV mechanics in healthy men performing 2 different time-under-tension protocols. Forty recreationally trained men (age: 23 ± 3 years) were randomized into 12 weeks of whole-body higher-repetition RT (20–25 repetitions/set to failure at ~30%–50% 1 repetition maximum (1RM); n = 13), lower-repetition RT (8–12 repetitions/set to failure at ~75%–90% 1RM; n = 13), or an active control period (n = 14). Speckle tracking echocardiography was performed at baseline and following the intervention period. Neither RT program altered standard measures of LV volumes (end-diastolic volume, end-systolic volume, or ejection fraction; P > 0.05) or indices of LV mechanics (total LV twist, untwisting rate, twist-to-shortening ratio, untwisting-to-twist ratio, or longitudinal strain; P > 0.05). This is the first longitudinal study to assess both LV size and mechanics after RT in healthy men, suggesting a maintenance of LV size and twist mechanics despite peripheral muscle adaptations to the training programs. These results provide no evidence for adverse LV structural or functional remodelling in response to RT in young men and support the positive role of RT in the maintenance of optimal cardiovascular function, even with strenuous RT.
Organisation(s): Sports and Health
External Organisation(s): McMaster University
Cardiff Metropolitan University
Columbia University
Type: Article
Journal: Applied Physiology, Nutrition and Metabolism
Volume: 44
Pages: 820-826
No. of pages: 7
ISSN: 1715-5312
Publication date: 08.01.2019
Publication status: Published
Peer reviewed: Yes
ASJC Scopus subject areas: Endocrinology, Diabetes and Metabolism, Physiology, Nutrition and Dietetics, Physiology (medical)
Sustainable Development Goals: SDG 3 - Good Health and Well-being
Electronic version(s): http://hdl.handle.net/10369/10713 (Access: Open)
https://doi.org/10.1139/apnm-2018-0544 (Access: Closed)