Identification, Crystal structure and antitumor activity of fusaric acid from the sugarcane fungal pathogen, Fusarium sacchari
- authored by
- Iman A.Y. Ghannam, Hanaa F. Roaiah, Mona M. Hanna, Sally S. El-Nakkady, Russell J. Cox
- Abstract
In this study, we investigated the secondary metabolic profile of the fungus Fusarium sacchari chromatographically. Fusaric acid and its analogs, fusaric acid methyl ester and 9,10-dehydrofusaric acid were identified and characterised by spectroscopic methods and reported for the first time as secondary metabolites isolated from the fungal extract of F. sacchari. The structure of fusaric acid was fully characterised by x-ray crystallography. Antitumor activity of fusaric acid was tested against larynx cell cancer line (HEP-2), breast cancer cell line (MCF-7), lung cancer cell line (A-549) and colon cancer cell line (HCT-116) and compared with cisplatin as a reference drug. Fusaric acid showed a moderate antitumor activity with IC50 65.9 μM against the HEP-2 cell line.
- External Organisation(s)
-
National Research Center, Cairo
Cairo University
University of Bristol
- Type
- Article
- Journal
- International Journal of Pharmacy and Technology
- Volume
- 6
- Pages
- 6528-6535
- No. of pages
- 8
- Publication date
- 01.07.2014
- Publication status
- Published
- Peer reviewed
- Yes
- ASJC Scopus subject areas
- Biomedical Engineering, Pharmacology, Toxicology and Pharmaceutics(all)
- Sustainable Development Goals
- SDG 3 - Good Health and Well-being
