Adapting the machine: adaptor proteins for Hsp100/Clp and AAA+ proteases

authored by

Janine Kirstein, Noël Molière, David A. Dougan, Kürşad Turgay

Abstract

Members of the AAA+ protein superfamily contribute to many diverse aspects of protein homeostasis in prokaryotic cells. As a fundamental component of numerous proteolytic machines in bacteria, AAA+ proteins play a crucial part not only in general protein quality control but also in the regulation of developmental programmes, through the controlled turnover of key proteins such as transcription factors. To manage these many, varied tasks, Hsp100/Clp and AAA+ proteases use specific adaptor proteins to enhance or expand the substrate recognition abilities of their cognate protease. Here, we review our current knowledge of the modulation of bacterial AAA+ proteases by these cellular arbitrators.

External Organisation(s)

Northwestern University
Freie Universität Berlin (FU Berlin)
La Trobe University

Type

Review article

Journal

Nature Reviews Microbiology

Volume

7

Pages

589-599

No. of pages

11

ISSN

1740-1526

Publication date

08.2009

Publication status

Published

Peer reviewed

Yes

ASJC Scopus subject areas

Microbiology, General Immunology and Microbiology, Infectious Diseases

Sustainable Development Goals

SDG 3 - Good Health and Well-being

Electronic version(s)

https://doi.org/10.1038/nrmicro2185 (Access: Closed)