Adapting the machine: adaptor proteins for Hsp100/Clp and AAA+ proteases

verfasst von

Janine Kirstein, Noël Molière, David A. Dougan, Kürşad Turgay

Abstract

Members of the AAA+ protein superfamily contribute to many diverse aspects of protein homeostasis in prokaryotic cells. As a fundamental component of numerous proteolytic machines in bacteria, AAA+ proteins play a crucial part not only in general protein quality control but also in the regulation of developmental programmes, through the controlled turnover of key proteins such as transcription factors. To manage these many, varied tasks, Hsp100/Clp and AAA+ proteases use specific adaptor proteins to enhance or expand the substrate recognition abilities of their cognate protease. Here, we review our current knowledge of the modulation of bacterial AAA+ proteases by these cellular arbitrators.

Externe Organisation(en)

Northwestern University
Freie Universität Berlin (FU Berlin)
La Trobe University

Typ

Übersichtsarbeit

Journal

Nature Reviews Microbiology

Band

7

Seiten

589-599

Anzahl der Seiten

11

ISSN

1740-1526

Publikationsdatum

08.2009

Publikationsstatus

Veröffentlicht

Peer-reviewed

Ja

ASJC Scopus Sachgebiete

Mikrobiologie, Allgemeine Immunologie und Mikrobiologie, Infektionskrankheiten

Ziele für nachhaltige Entwicklung

SDG 3 – Gute Gesundheit und Wohlergehen

Elektronische Version(en)

https://doi.org/10.1038/nrmicro2185 (Zugang: Geschlossen)