Synthesis of the northern hemisphere of amphidinolide H2
- authored by
- Florian P. Liesener, Ulrike Jannsen, Markus Kalesse
- Abstract
The stereoselective synthesis of the fully functionalized northern hemisphere of the marine natural product amphidinolide H2 is described. A vinylogous Mukaiyama aldol reaction and enzymatic desymmetrization of a meso compound are the key steps in the fragment synthesis. A stereoselective acetate aldol coupling and a 1,3-anti-reduction of the resulting β-hydroxy ketone complete the synthesis of the C14-C26 fragment.
- Organisation(s)
-
Institute of Organic Chemistry
- Type
- Article
- Journal
- Synthesis
- Pages
- 2590-2602
- No. of pages
- 13
- ISSN
- 0039-7881
- Publication date
- 01.08.2006
- Publication status
- Published
- Peer reviewed
- Yes
- ASJC Scopus subject areas
- Catalysis, Organic Chemistry
- Sustainable Development Goals
- SDG 14 - Life Below Water
- Electronic version(s)
-
https://doi.org/10.1055/s-2006-942459 (Access:
Unknown)
