Synthesis of the C1-C17 macrolactone of tedanolide
- authored by
- Jorma Hassfeld, Ulrike Eggert, Markus Kalesse
- Abstract
The vinylogous Mukaiyama aldol reaction is a useful method to build up complex polyketide structures. It is successfully employed in the synthesis of the C1-C17 macrolactone of tedanolide, a highly cytotoxic marine natural product. These studies present a practical approach toward the total synthesis of tedanolide; it is pursued using the appropriate C13-C23 segment that is introduced by a pivotal aldol reaction to join both hemispheres.
- Organisation(s)
-
Institute of Organic Chemistry
- Type
- Review article
- Journal
- Synthesis
- Pages
- 1183-1199
- No. of pages
- 17
- ISSN
- 0039-7881
- Publication date
- 02.05.2005
- Publication status
- Published
- Peer reviewed
- Yes
- ASJC Scopus subject areas
- Catalysis, Organic Chemistry
- Sustainable Development Goals
- SDG 14 - Life Below Water
- Electronic version(s)
-
https://doi.org/10.1055/s-2005-865302 (Access:
Unknown)
