Elucidation of the structure and intermolecular interactions of a reversible cyclic-peptide inhibitor of the proteasome by NMR spectroscopy and molecular modeling
- authored by
- Benjamin Stauch, Bernd Simon, Teodora Basile, Gisbert Schneider, Nisar P. Malek, Markus Kalesse, Teresa Carlomagno
- Abstract
chemical equation presentation Complex considerations: The proteasome plays a key role in diseases and is thus an appealing drug target. A structural model (see picture) of the proteasome as a complex with argyrin, a cyclic heptapeptide with antitumoral activity, provides a rationale for the high biological activity of this natural product. The structure-activity-relationship data available for the drug are discussed on the basis of this model.
- External Organisation(s)
-
European Molecular Biology Laboratory
ETH Zurich
Hannover Medical School (MHH)
Helmholtz Centre for Infection Research (HZI)
- Type
- Article
- Journal
- Angewandte Chemie - International Edition
- Volume
- 49
- Pages
- 3934-3938
- No. of pages
- 5
- ISSN
- 1433-7851
- Publication date
- 25.05.2010
- Publication status
- Published
- Peer reviewed
- Yes
- ASJC Scopus subject areas
- Catalysis, Chemistry(all)
- Sustainable Development Goals
- SDG 3 - Good Health and Well-being
- Electronic version(s)
-
https://doi.org/10.1002/anie.201000140 (Access:
Unknown)
