Engineered thiomarinol antibiotics active against MRSA are generated by mutagenesis and mutasynthesis of pseudoalteromonas SANK73390
- authored by
- Annabel C. Murphy, Daisuke Fukuda, Zhongshu Song, Joanne Hothersall, Russell J. Cox, Christine L. Willis, Christopher M. Thomas, Thomas J. Simpson
- Abstract
New drugs from marine bugs: The Japanese marine bacterium Pseudoalteromonas SANK73390 has been engineered to produce hybrid thiomarinol/pseudomonic acid compounds with potent activity against methicillin-resistant Staphylococcus aureus (MRSA). Previously unreported mupirocin and pyrrothine metabolites were isolated from wild-type and mutant strains and from mutagenesis experiments with mutant strains.
- External Organisation(s)
-
University of Bristol
University of Birmingham
- Type
- Article
- Journal
- Angewandte Chemie
- Volume
- 50
- Pages
- 3271-3274
- No. of pages
- 4
- ISSN
- 1433-7851
- Publication date
- 28.03.2011
- Publication status
- Published
- Peer reviewed
- Yes
- ASJC Scopus subject areas
- Catalysis, General Chemistry
- Sustainable Development Goals
- SDG 14 - Life Below Water
- Electronic version(s)
-
https://doi.org/10.1002/anie.201007029 (Access:
Closed)
https://doi.org/10.1002/ange.201007029 (Access: Closed)
