Engineered thiomarinol antibiotics active against MRSA are generated by mutagenesis and mutasynthesis of pseudoalteromonas SANK73390
- verfasst von
- Annabel C. Murphy, Daisuke Fukuda, Zhongshu Song, Joanne Hothersall, Russell J. Cox, Christine L. Willis, Christopher M. Thomas, Thomas J. Simpson
- Abstract
New drugs from marine bugs: The Japanese marine bacterium Pseudoalteromonas SANK73390 has been engineered to produce hybrid thiomarinol/pseudomonic acid compounds with potent activity against methicillin-resistant Staphylococcus aureus (MRSA). Previously unreported mupirocin and pyrrothine metabolites were isolated from wild-type and mutant strains and from mutagenesis experiments with mutant strains.
- Externe Organisation(en)
-
University of Bristol
University of Birmingham
- Typ
- Artikel
- Journal
- Angewandte Chemie
- Band
- 50
- Seiten
- 3271-3274
- Anzahl der Seiten
- 4
- ISSN
- 1433-7851
- Publikationsdatum
- 28.03.2011
- Publikationsstatus
- Veröffentlicht
- Peer-reviewed
- Ja
- ASJC Scopus Sachgebiete
- Katalyse, Allgemeine Chemie
- Ziele für nachhaltige Entwicklung
- SDG 14 – Lebensraum Wasser
- Elektronische Version(en)
-
https://doi.org/10.1002/anie.201007029 (Zugang:
Geschlossen)
https://doi.org/10.1002/ange.201007029 (Zugang: Geschlossen)
