Anti-obesity evaluation of Averrhoa carambola L. leaves and assessment of its polyphenols as potential α-glucosidase inhibitors

verfasst von

Nehal S Ramadan, Nabil H El-Sayed, Sayed A El-Toumy, Doha Abdou Mohamed, Zeinab Abdel Aziz, Mohamed Sobhy Marzouk, Tuba Esatbeyoglu, Mohamed A Farag, Kuniyoshi Shimizu

Abstract

Averrhoa carambola L. is reported for its anti-obese and anti-diabetic activities. The present study aimed to investigate its aqueous methanol leaf extract (CLL) in vivo anti-obese activity along with the isolation and identification of bioactive compounds and their in vitro α-glucosidase inhibition assessment. CLL improved all obesity complications and exhibited significant activity in an obese rat model. Fourteen compounds, including four flavone glycosides (

4) and ten dihydrochalcone glycosides (

12), were isolated and identified using spectroscopic techniques. New compounds identified in planta included (

1) apigenin 6-

C-(2-deoxy-

β-D-galactopyranoside)-7-

O-

β-D-quinovopyranoside, (

8) phloretin 3'-

C-(2-

O-(

E)-cinnamoyl-3-

O-

β-D-fucopyranosyl-4-

O-acetyl)-

β-D-fucopyranosyl-6'-

O-

β-D fucopyranosyl-(1/2)-α-L arabinofuranoside, (

11a) phloretin3'-

C-(2-

O-(

E)-p-coumaroyl-3-

O-

β-D-fucosyl-4-

O-acetyl)-

β-D-fucosyl-6'-

O-(2-

O-

β-D-fucosyl)-α-L-arabinofuranoside, (

11b) phloretin3'-

C-(2-O-

(Z)

-p-coumaroyl-3-

O-

β-D-fucosyl-4-

O-acetyl)-

β-D-fucosyl-6'-

O-(2-

O-

β-D-fucosyl)-α-L-arabinofuranoside. Carambolaside M (

5), carambolaside Ia (

6), carambolaside J (

7), carambolaside I (

9), carambolaside P (

10a), carambolaside O (

10b), and carambolaside Q (

12), which are reported for the first time from

A. carambola L. leaves, whereas luteolin 6-

C-α-L-rhamnopyranosyl-(1-2)-

β-D-fucopyranoside (

2), apigenin 6-

C-

β-D-galactopyranoside (

3), and apigenin 6-

C-

α-L-rhamnopyranosyl-(1-2)-

β-L-fucopyranoside (

4) are isolated for the first time from Family. Oxalidaceae. In vitro α-glucosidase inhibitory activity revealed the potential efficacy of flavone glycosides, viz.,

3, and

4 as antidiabetic agents. In contrast, dihydrochalcone glycosides (

11) showed weak activity, except for compound

12, which showed relatively strong activity.

Organisationseinheit(en)

Institut für Lebensmittelwissenschaft und Humanernährung
Molekulare Lebensmittelchemie und -entwicklung

Externe Organisation(en)

National Research Centre (NRC)
Cairo University
Kyushu University

Typ

Artikel

Journal

Molecules

Band

ISSN

1420-3049

Publikationsdatum

12.08.2022

Publikationsstatus

Veröffentlicht

Peer-reviewed

Ziele für nachhaltige Entwicklung

SDG 3 – Gute Gesundheit und Wohlergehen

Elektronische Version(en)

https://doi.org/10.3390/molecules27165159 (Zugang: Offen)