In Vivo Imaging of Drug Action

verfasst von

Oliver Plettenburg, Matthias Löhn

Abstract

In vivo imaging has evolved to be one of the most powerful methods to assist modern drug development, and to enable monitoring of disease progression in longitudinal studies by noninvasive methods in living animals. This chapter discusses the general principles and concepts of in vivo imaging and probe design, that are used to visualize the distribution behavior and effects of drug treatment. It provides some selected case studies in the areas of oncology, CNS, and diabetes. Some examples for translating these results into clinical practice are also discussed. The imaging techniques discussed in the chapter are magnetic resonance imaging (MRI), X-ray computer tomography (CT), single-photon emission computed tomography (SPECT), positron emission tomography (PET), and fluorescence-or luminescence-based technologies. Key to success is an early, reliable diagnosis, and allowing clear assessment of the actual disease stage, thus opening up opportunities for therapeutic intervention at an early point in time.

Externe Organisation(en)

Sanofi-Aventis Deutschland GmbH

Typ

Beitrag in Buch/Sammelwerk

Seiten

465-501

Anzahl der Seiten

37

Publikationsdatum

26.09.2015

Publikationsstatus

Veröffentlicht

Peer-reviewed

Ja

ASJC Scopus Sachgebiete

Chemie (insg.), Chemische Verfahrenstechnik (insg.), Biochemie, Genetik und Molekularbiologie (insg.)

Ziele für nachhaltige Entwicklung

SDG 3 – Gute Gesundheit und Wohlergehen

Elektronische Version(en)

https://doi.org/10.1002/9781118771723.ch16 (Zugang: Geschlossen)