Regulation of autophagy as a therapy for immunosenescence-driven cancer and neurodegenerative diseases: The role of exercise

verfasst von

Helena Angelica Pereira Batatinha, Tiego Aparecido Diniz, Alexandre Abilio de Souza Teixeira, K. Krüger, Jose Cesar Rosa Neto

Abstract

Aging is one of the risk factors for the development of low-grade inflammation morbidities, such as several types of cancer and neurodegenerative diseases, due to changes in the metabolism, hormonal secretion, and immunosenescence. The senescence of the immune system leads to improper control of infections and tissue damage increasing age-related diseases. One of the mechanisms that maintain cellular homeostasis is autophagy, a cell-survival mechanism, and it has been proposed as one of the most powerful antiaging therapies. Regular exercise can reestablish autophagy, probably through AMP-activated protein kinase activation, and help in reducing the age-related senescence diseases. Therefore, in this study, we discuss the effects of exercise training in immunosenescence and autophagy, preventing the two main age-related disease, cancer and neurodegeneration.

Organisationseinheit(en)

Institut für Sportwissenschaft

Externe Organisation(en)

Universidade de Sao Paulo

Typ

Übersichtsarbeit

Journal

Journal of Celluar Physiology

Band

234

Seiten

14883-14895

Anzahl der Seiten

13

Publikationsdatum

24.05.2019

Publikationsstatus

Veröffentlicht

Peer-reviewed

Ja

ASJC Scopus Sachgebiete

Physiologie, Klinische Biochemie, Zellbiologie

Ziele für nachhaltige Entwicklung

SDG 3 – Gute Gesundheit und Wohlergehen

Elektronische Version(en)

https://doi.org/10.1002/jcp.28318 (Zugang: Geschlossen)