Towards Interpretable Hybrid AI

Integrating Knowledge Graphs and Symbolic Reasoning in Medicine

verfasst von

Yashrajsinh Chudasama, Hao Huang, Disha Purohit, Maria Esther Vidal

Abstract

Knowledge Graphs (KGs) are data structures that enable the integration of heterogeneous data sources and supporting both knowledge representation and formal reasoning. In this paper, we introduce TrustKG, a KG-based framework designed to enhance the interpretability and reliability of hybrid AI systems in healthcare. Positioned within the context of lung cancer, TrustKG supports link prediction, which uncovers hidden relationships within medical data, and counterfactual prediction, which explores alternative scenarios to understand causal factors. These tasks are addressed through two specialized hybrid AI systems, VISE and HealthCareAI, which combine symbolic reasoning with inductive learning over KGs to provide interpretable AI solutions for clinical decision-making. Leveraging KGs to represent biomedical properties and relationships, and augmenting them with learned patterns through symbolic reasoning, our hybrid approach produces models that are both accurate and transparent. This interpretability is particularly important in medical applications, where trust and reliability in AI-driven predictions are paramount. Our empirical analysis demonstrates the effectiveness of VISE and HealthCareAI in improving the predictive accuracy and clarity of model outputs. By addressing challenges in link prediction - such as discovering previously unknown connections between medical entities - and in counterfactual prediction, TrustKG, with VISE and HealthCareAI, underscores the potential of integrating KGs with symbolic AI to create trustworthy, interpretable AI systems in healthcare. This paper contributes to the advancement of semantic AI, offering a pathway for robust and reliable AI solutions in clinical settings.

Organisationseinheit(en)

Institut für Data Science
Forschungszentrum L3S

Externe Organisation(en)

Technische Informationsbibliothek (TIB) Leibniz-Informationszentrum Technik und Naturwissenschaften und Universitätsbibliothek

Typ

Artikel

Journal

IEEE ACCESS

Anzahl der Seiten

22

ISSN

2169-3536

Publikationsdatum

13.01.2025

Publikationsstatus

Elektronisch veröffentlicht (E-Pub)

Peer-reviewed

Ja

ASJC Scopus Sachgebiete

Allgemeine Computerwissenschaft, Allgemeine Materialwissenschaften, Allgemeiner Maschinenbau

Ziele für nachhaltige Entwicklung

SDG 3 – Gute Gesundheit und Wohlergehen

Elektronische Version(en)

https://doi.org/10.1109/ACCESS.2025.3529133 (Zugang: Offen)