Simultaneous cancer control and diagnosis with magnetic nanohybrid materials
- verfasst von
- Franz Renz, Reza Saadat
- Abstract
Coated magnetite nanoparticles were linked to 68Ga complexes used in the positron emission tomography (PET) for a new technical approach to detect cancer tissue with radiopharmaceuticals. By substitution of the Ga isotope with an alpha emitter the same compound could be used for cancer treatment. Furthermore the nanoparticles were connected to pH-sensitive complexes, enabling a pH-controlled assembly/disassembly and therefore the spreading of the particles in the tissue. With this novel method of combining detection and treatment simultaneously, the amount of medical exposure could be minimized for the patient. The results demonstrate that magnetite nanoparticles can effectively be functionalized with PET isotopes and pH sensitive complexes in order to use them as a new type of radiopharmaceuticals.
- Organisationseinheit(en)
-
Institut für Anorganische Chemie
- Typ
- Letter
- Journal
- Beilstein Journal of Nanotechnology
- Band
- 7
- Seiten
- 121-125
- Anzahl der Seiten
- 5
- ISSN
- 2190-4286
- Publikationsdatum
- 27.01.2016
- Publikationsstatus
- Veröffentlicht
- Peer-reviewed
- Ja
- ASJC Scopus Sachgebiete
- Allgemeine Materialwissenschaften, Allgemeine Physik und Astronomie, Elektrotechnik und Elektronik
- Ziele für nachhaltige Entwicklung
- SDG 3 – Gute Gesundheit und Wohlergehen
- Elektronische Version(en)
-
https://doi.org/10.3762/bjnano.7.14 (Zugang:
Offen)
