Telemonitoring-Supported Exercise Training in Employees With Metabolic Syndrome Improves Liver Inflammation and Fibrosis

verfasst von

Sven Haufe, Katharina L. Hupa-Breier, Pauline Bayerle, Hedwig T. Boeck, Simone Rolff, Thorben Sundermeier, Arno Kerling, Julian Eigendorf, Momme Kück, Alexander A. Hanke, Ralf Ensslen, Lars Nachbar, Dirk Lauenstein, Dietmar Böthig, Denise Hilfiker-Kleiner, Meike Stiesch, Christoph Terkamp, Heiner Wedemeyer, Axel Haverich, Uwe Tegtbur

Abstract

INTRODUCTION: Metabolic syndrome (MetS) is a major health problem worldwide and the main risk factor for metabolic-associated fatty liver disease (MAFLD). Established treatment options are lifestyle interventions facilitating dietary change and increased physical activity. Here, we tested the effect of a telemonitoring-supported intervention on liver parameter of inflammation and fibrosis in individuals with MetS. METHODS: This was a prospective, randomized, parallel-group, and assessor-blind study performed in workers of the main Volkswagen factory (Wolfsburg, Germany). Volunteers with diagnosed MetS were randomly assigned (1:1) to a 6-month lifestyle intervention focusing on supervised, activity-tracker-guided exercise or to a waiting-list control group. This secondary analysis assessed the effect of the intervention on liver enzymes and MAFLD-related parameters. RESULTS: We screened 543 individuals between October 10, 2017, and February 27, 2018, of whom 314 were randomly assigned to the intervention group (n = 160) or control group (n = 154). Liver transaminases, alkaline phosphatase, and gamma-glutamyl transferase significantly decreased after 6 months in the intervention group compared with the CG. Furthermore, an aspartate aminotransferase-to-platelet ratio index score as a marker for liver fibrosis significantly decreased in the intervention group. These improvements were associated with changes in obesity and exercise capacity. DISCUSSION: A 6-month lifestyle intervention based on exercise training with individualized telemonitoring-based supervision led to improvements of liver inflammation and fibrosis in employees with MetS. Therefore, this intervention shows therapeutic potential for individuals at high risk of MAFLD (ClinicalTrials.gov Identifier: NCT03293264).

Organisationseinheit(en)

Institut für Sportwissenschaft

Externe Organisation(en)

Medizinische Hochschule Hannover (MHH)
Audi BKK
Volkswagen AG

Typ

Artikel

Journal

Clinical and Translational Gastroenterology

Band

12

ISSN

2155-384X

Publikationsdatum

06.2021

Publikationsstatus

Veröffentlicht

Peer-reviewed

Ja

ASJC Scopus Sachgebiete

Gastroenterologie

Ziele für nachhaltige Entwicklung

SDG 3 – Gute Gesundheit und Wohlergehen

Elektronische Version(en)

https://doi.org/10.14309/ctg.0000000000000371 (Zugang: Offen)