Plasma malondialdehyde and risk of new-onset diabetes after transplantation in renal transplant recipients: A prospective cohort study

verfasst von

Manuela Yepes-Calderón, Camilo G. Sotomayor, António W. Gomes-Neto, Rijk O.B. Gans, Stefan P. Berger, G. Rimbach, Tuba Esatbeyoglu, Ramón Rodrigo, Johanna M. Geleijnse , Gerjan J. Navis, Stephan J.L. Bakker

Abstract

New-onset diabetes after transplantation (NODAT) is a frequent complication in renal transplant recipients (RTR). Although oxidative stress has been associated with diabetes mellitus, data regarding NODAT are limited. We aimed to prospectively investigate the long-term association between the oxidative stress biomarker malondialdehyde (measured by high-performance liquid chromatography) and NODAT in an extensively phenotyped cohort of non-diabetic RTR with a functioning graft ≥1 year. We included 516 RTR (51 ± 13 years-old, 57% male). Median plasma malondialdehyde (MDA) was 2.55 (IQR, 1.92-3.66) µmol/L. During a median follow-up of 5.3 (IQR, 4.6-6.0) years, 56 (11%) RTR developed NODAT. In Cox proportional-hazards regression analyses, MDA was inversely associated with NODAT, independent of immunosuppressive therapy, transplant-specific covariates, lifestyle, inflammation, and metabolism parameters (HR, 0.55; 95% CI, 0.36-0.83 per 1-SD increase;

p < 0.01). Dietary antioxidants intake (e.g., vitamin E, α-lipoic acid, and linoleic acid) were effect-modifiers of the association between MDA and NODAT, with particularly strong inverse associations within the subgroup of RTR with relatively higher dietary antioxidants intake. In conclusion, plasma MDA concentration is inversely and independently associated with long-term risk of NODAT in RTR. Our findings support a potential underrecognized role of oxidative stress in post-transplantation glucose homeostasis.

Organisationseinheit(en)

Institut für Lebensmittelwissenschaft und Humanernährung

Externe Organisation(en)

University Medical Center Groningen (UMCG)
Universidad de Chile
Wageningen University and Research

Typ

Artikel

Journal

Journal of Clinical Medicine

Band

ISSN

2077-0383

Publikationsdatum

04.2019

Publikationsstatus

Veröffentlicht

Peer-reviewed

ASJC Scopus Sachgebiete

Medizin (insg.)

Ziele für nachhaltige Entwicklung

SDG 3 – Gute Gesundheit und Wohlergehen

Elektronische Version(en)

https://doi.org/10.3390/jcm8040453 (Zugang: Offen)
https://doi.org/10.15488/10958 (Zugang: Offen)