Fast Orthogonal Separation by Superposition of Time of Flight and Field Asymmetric Ion Mobility Spectrometry

verfasst von

Alexander Bohnhorst, Ansgar T. Kirk, Marc Berger, Stefan Zimmermann

Abstract

Ion mobility spectrometry is a powerful and low-cost technique for the identification of chemical warfare agents, toxic chemicals, or explosives in air. Drift tube ion mobility spectrometers (DT-IMS) separate ions by the absolute value of their low field ion mobility, while field asymmetric ion mobility spectrometers (FAIMS) separate them by the change of their ion mobility at high fields. However, using one of these devices alone, some common and harmless substances show the same response as the hazardous target substances. In order to increase the selectivity, orthogonal data are required. Thus, in this work, we present for the first time an ambient pressure ion mobility spectrometer which is able to separate ions both by their differential and low field mobility, providing additional information for selectivity enhancement. This novel field asymmetric time of flight ion mobility spectrometer (FAT-IMS) allows high repetition rates and reaches limits of detection in the low ppb range common for DT-IMS. The device consists of a compact 44 mm drift tube with a tritium ionization source and a resolving power of 70. An increased separation of four substances with similar low field ion mobility is shown: phosgene (K₀ = 2.33 cm²/(V s)), 1,1,2-trichlorethane (K₀ = 2.31 cm²/(V s)), chlorine (K₀ = 2.24 cm²/(V s)), and nitrogen dioxide (K₀ = 2.25 cm²/(V s)). Furthermore, the behavior and limits of detection for acetonitrile, dimethyl methylphosphonate, diisopropyl methyl phosphonate in positive polarity and carbon dioxide, sulfur dioxide, hydrochloric acid, cyanogen chloride, and hydrogen cyanide in negative polarity are investigated.

Organisationseinheit(en)

Institut für Grundlagen der Elektrotechnik und Messtechnik

Typ

Artikel

Journal

Analytical chemistry

Band

90

Seiten

1114-1121

Anzahl der Seiten

8

ISSN

0003-2700

Publikationsdatum

22.12.2017

Publikationsstatus

Veröffentlicht

Peer-reviewed

Ja

ASJC Scopus Sachgebiete

Analytische Chemie

Ziele für nachhaltige Entwicklung

SDG 12 – Verantwortungsvoller Konsum und Produktion

Elektronische Version(en)

https://doi.org/10.1021/acs.analchem.7b03200 (Zugang: Geschlossen)