Graphene-enhanced PCL electrospun nanofiber scaffolds for cardiac tissue engineering

verfasst von

Ana M. Muñoz-Gonzalez, Sara Leal-Marin, Dianney Clavijo-Grimaldo, Birgit Glasmacher

Abstract

Cardiovascular diseases, particularly myocardial infarction, have significant healthcare challenges due to the limited regenerative capacity of injured heart tissue. Cardiac tissue engineering (CTE) offers a promising approach to repairing myocardial damage using biomaterials that mimic the heart’s extracellular matrix. This study investigates the potential of graphene nanopowder (Gnp)-enhanced polycaprolactone (PCL) scaffolds fabricated via electrospinning to improve the properties necessary for effective cardiac repair. This work aimed to analyze scaffolds with varying graphene concentrations (0.5%, 1%, 1.5%, and 2% by weight) to determine their morphological, chemical, mechanical, and biocompatibility characteristics. The results presented that incorporating graphene improves PCL scaffolds’ mechanical properties and cellular interactions. The optimal concentration of 1% graphene significantly enhanced mechanical properties and biocompatibility, promoting cell adhesion and proliferation. These findings suggest that Gnp-enhanced PCL scaffolds at this concentration can serve as a potent substrate for CTE providing insights into designing more effective biomaterials for myocardial restoration.

Organisationseinheit(en)

Institut für Mehrphasenprozesse

Externe Organisation(en)

Universidad Nacional de Colombia
NIFE- Niedersächsisches Zentrum für Biomedizintechnik, Implantatforschung und Entwicklung
Grupo INPAC. Fundación Universitaria Sanitas

Typ

Artikel

Journal

International Journal of Artificial Organs

Band

47

Seiten

633-641

Anzahl der Seiten

9

ISSN

0391-3988

Publikationsdatum

08.2024

Publikationsstatus

Veröffentlicht

Peer-reviewed

Ja

ASJC Scopus Sachgebiete

Bioengineering, Medizin (sonstige), Biomaterialien, Biomedizintechnik

Ziele für nachhaltige Entwicklung

SDG 3 – Gute Gesundheit und Wohlergehen

Elektronische Version(en)

https://doi.org/10.1177/03913988241266088 (Zugang: Offen)