Modifications of the closure principle for analyzing toxicological studies
- verfasst von
- Ludwig A. Hothorn
- Abstract
A Drug Information Association Workshop on “Statistical Methodology on Non-Clinical and Toxicological Studies” was held on March, 25-27, 1996. The purpose of this meeting was to discuss the appropriateness of current and new biostatistical methods in this field of drug development. This paper proposes a simple closure test for dose-response relationships under real data conditions. This approach takes into account deviation from variance homogeneity and monotonicity assumptions. Moreover, this approach can be easily adapted for “any” kind of two-sample tests, for example, nonparametric, dichotomous, censored, and so forth. Power was compared by a simulation study for selected conditions.
- Organisationseinheit(en)
-
Abteilung Biostatistik
- Typ
- Artikel
- Journal
- Therapeutic Innovation & Regulatory Science
- Band
- 31
- Seiten
- 403-412
- Anzahl der Seiten
- 10
- ISSN
- 2168-4790
- Publikationsdatum
- 30.12.1997
- Publikationsstatus
- Veröffentlicht
- Peer-reviewed
- Ja
- ASJC Scopus Sachgebiete
- Pharmakologie, Toxikologie und Pharmazie (sonstige), Öffentliche Gesundheit, Umwelt- und Arbeitsmedizin, Pharmakologie (medizinische)
- Ziele für nachhaltige Entwicklung
- SDG 3 – Gute Gesundheit und Wohlergehen
- Elektronische Version(en)
-
https://doi.org/10.1177/009286159703100211 (Zugang:
Geschlossen)
https://doi.org/10.15488/3022 (Zugang: Offen)
