Mechanical ventilation in a conscious male during exercise

A case report

verfasst von

Sarah Anne Angus, Joshua L Taylor, Leah Mann, Alex Williams, Eric J Stöhr, Jason S Au, Andrew William Sheel, Paolo B Dominelli

Abstract

We recently explored the cardiopulmonary interactions during partial unloading of the respiratory muscles during exercise. Expanding upon this work, we present a noteworthy case study whereby we eliminated the influence of respiration on cardiac function in a conscious but mechanically ventilated human during exercise. This human was a young healthy endurance-trained male who was mechanically ventilated during semi-recumbent cycle exercise at 75 Watts (W) (~30% Wmax). During mechanically ventilated exercise, esophageal pressure was reduced to levels indistinguishable from the cardiac artefact which led to a 94% reduction in the work of breathing. The reduction in respiratory pressures and respiratory muscle work led to a decrease in cardiac output (-6%), which was due to a reduction in stroke volume (-13%), left ventricular end-diastolic volume (-15%) and left-ventricular end-systolic volume (-17%) that was not compensated for by heart rate. Our case highlights the influence of extreme mechanical ventilation on cardiac function while noting the possible presence of a maximal physiological limit to which respiration (and its associated pressures) impacts cardiac function when the work of breathing is maximally reduced.

Organisationseinheit(en)

Institut für Sportwissenschaft

Externe Organisation(en)

University of Waterloo
University of British Columbia
Columbia University Irving Medical Center

Typ

Artikel

Journal

Applied Physiology, Nutrition and Metabolism

Band

49

Seiten

1436 - 1440

Anzahl der Seiten

5

ISSN

1715-5312

Publikationsdatum

10.2024

Publikationsstatus

Veröffentlicht

Peer-reviewed

Ja

ASJC Scopus Sachgebiete

Physiologie (medizinische), Ernährung und Diätetik, Physiologie, Endokrinologie, Diabetes und Stoffwechsel

Ziele für nachhaltige Entwicklung

SDG 3 – Gute Gesundheit und Wohlergehen

Elektronische Version(en)

https://doi.org/10.1139/apnm-2024-0100 (Zugang: Geschlossen)