Nichtalkoholische Fettlebererkrankung

verfasst von

Nicolai Worm, J. Stein, A. Ströhle

Abstract

Nonalcoholic fatty liver disease (NAFLD) is defined as hepatic steatosis without significant alcohol-related or other causes of secondary steatosis, and is the most widespread liver disease in the industrialised world with around 20-30 % of the global population affected. NAFLD ranges from steatosis on its own (NAFL) to nonalcoholic steatohepatitis (NASH) and cirrhosis, and on towards hepatocellular carcinoma (HCC). NAFLD development is multifactorial with influences including genetic and epigenetic, hormonal and environmental factors, and especially lifestyle. Peripheral and hepatic insulin resistance is a common link to the established risk factors that include visceral obesity, hyper- caloric diet, and lack of physical activity. NAFLD is not an isolated liver disease as it causes a variety of metabolic disorders including type 2 diabetes, kidney disease, and atherosclerotic issues such as coronary heart disease. NAFLD is diagnosed using imaging procedures, especially sonography, and biochemical and anthropometric data in routine clinical practice; treatment involves lifestyle intervention consisting of exercise and nutritional therapy.

Organisationseinheit(en)

Institut für Lebensmittelwissenschaft und Humanernährung
Abteilung Ernährungsphysiologie und Humanernährung

Externe Organisation(en)

Deutsche Hochschule für Prävention und Gesundheitsmanagement Saarbrücken

Typ

Artikel

Journal

Diabetes, Stoffwechsel und Herz

Band

25

Seiten

85-94

Anzahl der Seiten

10

ISSN

1861-7603

Publikationsdatum

04.2016

Publikationsstatus

Veröffentlicht

ASJC Scopus Sachgebiete

Innere Medizin, Endokrinologie, Diabetes und Stoffwechsel, Endokrinologie

Ziele für nachhaltige Entwicklung

SDG 3 – Gute Gesundheit und Wohlergehen