Statistical Analysis of in Vivo Anticancer Experiments

Tumor Growth Inhibition

verfasst von

Ludwig A. Hothorn

Abstract

Tumor growth inhibition data in in vivo anticancer experiments are commonly analyzed using the treatment-to-control ratio (TCR). Parametric and nonparametric confidence interval approaches for this ratio are introduced, enabling a quantitative statistical decision. The growth curves are characterized by the area-under-the-curve technique, adjusted for animal-specific survival. Simple simultaneous approaches are proposed for complex designs, including several treatment or dose groups. This implementation makes decision making easier for the pharmacologists through the use of simple diagrams for the treatment-to-control ratios and their confidence intervals. Tumor inhibition and regression can be appropriately statistically analyzed by treatment-to-control ratios and their confidence intervals.

Organisationseinheit(en)

Abteilung Biostatistik

Typ

Artikel

Journal

Therapeutic Innovation & Regulatory Science

Band

40

Seiten

229-238

Anzahl der Seiten

10

ISSN

2168-4790

Publikationsdatum

30.12.2006

Publikationsstatus

Veröffentlicht

Peer-reviewed

Ja

ASJC Scopus Sachgebiete

Pharmakologie, Toxikologie und Pharmazie (sonstige), Öffentliche Gesundheit, Umwelt- und Arbeitsmedizin, Pharmakologie (medizinische)

Ziele für nachhaltige Entwicklung

SDG 3 – Gute Gesundheit und Wohlergehen

Elektronische Version(en)

https://doi.org/10.1177/009286150604000212 (Zugang: Geschlossen)
https://doi.org/10.15488/3051 (Zugang: Offen)