Advanced therapy medicinal products and health technology assessment principles and practices for value-based and sustainable healthcare

verfasst von

Bengt Jönsson, Grace Hampson, Jonathan Michaels, Adrian Towse, J. Matthias Graf von der Schulenburg, Olivier Wong

Abstract

Background: Advanced therapy medicinal products (ATMPs) are beginning to reach European markets, and questions are being asked about their value for patients and how healthcare systems should pay for them. Objectives: To identify and discuss potential challenges of ATMPs in view of current health technology assessment (HTA) methodology—specifically economic evaluation methods—in Europe as it relates to ATMPs, and to suggest potential solutions to these challenges. Methods: An Expert Panel reviewed current HTA principles and practices in relation to the specific characteristics of ATMPs. Results: Three key topics were identified and prioritised for discussion—uncertainty, discounting, and health outcomes and value. The panel discussed that evidence challenges linked to increased uncertainty may be mitigated by collection of follow-on data, use of value of information analysis, and/or outcomes-based contracts. For discount rates, an international, multi-disciplinary forum should be established to consider the economic, social and ethical implications of the choice of rate. Finally, consideration of the feasibility of assessing the value of ATMPs beyond health gain may also be key for decision-making. Conclusions: ATMPs face a challenge in demonstrating their value within current HTA frameworks. Consideration of current HTA principles and practices with regards to the specific characteristics of ATMPs and continued dialogue will be key to ensuring appropriate market access. Classification code: I.

Organisationseinheit(en)

Institut für Versicherungsbetriebslehre

Externe Organisation(en)

Handelshögskolan i Stockholm (HHS)
The University of Sheffield
Office of Health Economics (OHE)
Medi-Qualite Omega

Typ

Artikel

Journal

European Journal of Health Economics

Band

20

Seiten

427-438

Anzahl der Seiten

12

ISSN

1618-7598

Publikationsdatum

01.04.2019

Publikationsstatus

Veröffentlicht

Peer-reviewed

Ja

ASJC Scopus Sachgebiete

Volkswirtschaftslehre, Ökonometrie und Finanzen (sonstige), Health policy

Ziele für nachhaltige Entwicklung

SDG 3 – Gute Gesundheit und Wohlergehen

Elektronische Version(en)

https://doi.org/10.1007/s10198-018-1007-x (Zugang: Offen)