Molecular docking and metagenomics assisted mitigation of microplastic pollution

verfasst von

Dinesh Parida, Konica Katare, Atmaadeep Ganguly, Disha Chakraborty, Oisi Konar, Regina Nogueira, Kiran Bala

Abstract

Microplastics, tiny, flimsy, and direct progenitors of principal and subsidiary plastics, cause environmental degradation in aquatic and terrestrial entities. Contamination concerns include irrevocable impacts, potential cytotoxicity, and negative health effects on mortals. The detection, recovery, and degradation strategies of these pollutants in various biota and ecosystems, as well as their impact on plants, animals, and humans, have been a topic of significant interest. But the natural environment is infested with several types of plastics, all having different chemical makeup, structure, shape, and origin. Plastic trash acts as a substrate for microbial growth, creating biofilms on the plastisphere surface. This colonizing microbial diversity can be glimpsed with meta-genomics, a culture-independent approach. Owing to its comprehensive description of microbial communities, genealogical evidence on unconventional biocatalysts or enzymes, genomic correlations, evolutionary profile, and function, it is being touted as one of the promising tools in identifying novel enzymes for the degradation of polymers. Additionally, computational tools such as molecular docking can predict the binding of these novel enzymes to the polymer substrate, which can be validated through in vitro conditions for its environmentally feasible applications. This review mainly deals with the exploration of metagenomics along with computational tools to provide a clearer perspective into the microbial potential in the biodegradation of microplastics. The computational tools due to their polymathic nature will be quintessential in identifying the enzyme structure, binding affinities of the prospective enzymes to the substrates, and foretelling of degradation pathways involved which can be quite instrumental in the furtherance of the plastic degradation studies.

Organisationseinheit(en)

Institut für Siedlungswasserwirtschaft und Abfalltechnik

Externe Organisation(en)

Indian Institute of Technology Indore (IITI)
University of Calcutta
West Bengal State University (WBSU)

Typ

Übersichtsarbeit

Journal

CHEMOSPHERE

Band

351

Anzahl der Seiten

17

ISSN

0045-6535

Publikationsdatum

03.2024

Publikationsstatus

Veröffentlicht

Peer-reviewed

Ja

ASJC Scopus Sachgebiete

Environmental engineering, Umweltchemie, Chemie (insg.), Umweltverschmutzung, Öffentliche Gesundheit, Umwelt- und Arbeitsmedizin, Gesundheit, Toxikologie und Mutagenese

Ziele für nachhaltige Entwicklung

SDG 3 – Gute Gesundheit und Wohlergehen, SDG 15 – Lebensraum Land

Elektronische Version(en)

https://doi.org/10.1016/j.chemosphere.2024.141271 (Zugang: Geschlossen)