Multifunctional croconaine nanoparticles for efficient optoacoustic imaging of deep tumors and photothermal therapy

verfasst von

Nian Liu, Patrick O'Connor, Vipul Gujrati, Pia Anzenhofer, Uwe Klemm, Karin Kleigrewe, Michael Sattler, Oliver Plettenburg, Vasilis Ntziachristos

Abstract

The proper design of near-infrared light-absorbing agents enables efficient optoacoustic imaging-guided phototherapy. In particular, several croconaine-based organic agents with excellent optical properties have been recently reported for this purpose. However, most of them absorb light below 800 nm, limiting deep-tissue imaging applications. To this end, we utilized a recently described novel croconaine derivative (CR880) to develop CR880-based nanoparticles (CR880-NPs) for effective in vivo delivery, deep tissue optoacoustic imaging and photothermal therapy applications. Radicals and strong π-πstacking in CR880 result in an 880 nm absorption peak with no blue-shift upon condensing to the solid phase. DSPE-PEG2000-formulated CR880-NPs exhibited high optoacoustic generation efficiency and photostability, and could be visualized in the tumors of three different mouse tumor models (breast, brain, and colon tumor) with high image contrast. The high photothermal conversion efficiency of CR880-NPs (∼58%) subsequently enabled efficient in vivo tumor elimination using a low energy laser, while remaining biocompatible and well-tolerated. This work introduces a promising novel agent for cancer theranostics of challenging deep-seated tumors.

Organisationseinheit(en)

Zentrum für Biomolekulare Wirkstoffe (BMWZ)

Externe Organisation(en)

Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt
Technische Universität München (TUM)
Zhejiang University

Typ

Artikel

Journal

Nanophotonics

Band

11

Seiten

4637-4647

Anzahl der Seiten

11

ISSN

2192-8606

Publikationsdatum

12.2022

Publikationsstatus

Veröffentlicht

Peer-reviewed

Ja

ASJC Scopus Sachgebiete

Biotechnologie, Elektronische, optische und magnetische Materialien, Atom- und Molekularphysik sowie Optik, Elektrotechnik und Elektronik

Ziele für nachhaltige Entwicklung

SDG 3 – Gute Gesundheit und Wohlergehen

Elektronische Version(en)

https://doi.org/10.1515/nanoph-2022-0469 (Zugang: Offen)