Targeting heat-shock-protein 90 (Hsp90) by natural products

Geldanamycin, a show case in cancer therapy

verfasst von

Jana Franke, Simone Eichner, Carsten Zeilinger, Andreas Kirschning

Abstract

Covering: 2005 to 2013 In this review recent progress in the development of heat shock proteins (Hsp90) in oncogenesis is illuminated. Particular emphasis is put on inhibitors such as geldanamycin and analogues that serve as a natural product show case. Hsp90 has emerged as an important target in cancer therapy and/or against pathogenic cells which elicit abnormal Hsp patterns. Competition for ATP by geldanamycin and related compounds abrogate the chaperone function of Hsp90. In this context, this account pursues three topics in detail: a) Hsp90 and its biochemistry, b) Hsp90 and its role in oncogenesis and c) strategies to create compound libraries of structurally complex inhibitors like geldanamycin on which SAR studies and the development of drugs that are currently in different stages of clinical testing rely.

Organisationseinheit(en)

Abteilung Zellphysiologie und Biophysik
Zentrum für Biomolekulare Wirkstoffe (BMWZ)
Institut für Organische Chemie

Typ

Übersichtsarbeit

Journal

Natural Product Reports

Band

30

Seiten

1299-1323

Anzahl der Seiten

25

ISSN

0265-0568

Publikationsdatum

10.2013

Publikationsstatus

Veröffentlicht

Peer-reviewed

Ja

ASJC Scopus Sachgebiete

Biochemie, Wirkstoffforschung, Organische Chemie

Ziele für nachhaltige Entwicklung

SDG 3 – Gute Gesundheit und Wohlergehen

Elektronische Version(en)

https://doi.org/10.1039/c3np70012g (Zugang: Unbekannt)